Cis regulatory control during development
Our lab is interested in understanding how cis-regulatory elements control cell fate decisions during development. While we know these non-coding sequences control gene expression, how they achieve this is still not understood. We have a particular interest in repressors, and how they act via cis-regulatory elements to mediate gene silencing.
We do this by combining stem-cell derived and in vivo models. By using state-of-the-art genomics, proteomics and microscopy approaches, we aim at understanding gene regulatory control by non-coding DNA elements at a molecular level during developmental cell fate decisions.